Chromatin Structure and Dynamics
نویسندگان
چکیده
منابع مشابه
Chromatin Structure in Telomere Dynamics
The establishment of a specific nucleoprotein structure, the telomere, is required to ensure the protection of chromosome ends from being recognized as DNA damage sites. Telomere shortening below a critical length triggers a DNA damage response that leads to replicative senescence. In normal human somatic cells, characterized by telomere shortening with each cell division, telomere uncapping is...
متن کاملChromatin higher-order structure and dynamics.
The primary role of the nucleus as an information storage, retrieval, and replication site requires the physical organization and compaction of meters of DNA. Although it has been clear for many years that nucleosomes constitute the first level of chromatin compaction, this contributes a relatively small fraction of the condensation needed to fit the typical genome into an interphase nucleus or...
متن کاملStructure and dynamics of transcriptionally active chromatin.
Chromatin is a highly dynamic macromolecular complex that undergoes continuous structural modification during the various stages of genetic activity. Such dynamic behavior is the result of a complex and perfectly balanced network of interactions involving histones, DNA and ions in an aqueous environment. In the past eighteen years since the discovery of the nucleosome particle, a great deal of ...
متن کاملComputational modeling predicts the structure and dynamics of chromatin fiber.
BACKGROUND The compact form of the chromatin fiber is a critical regulator of fundamental processes such as transcription and replication. These reactions can occur only when the fiber is unraveled and the DNA strands contained within are exposed to interact with nuclear proteins. While progress on identifying the biochemical mechanisms that control localized folding and hence govern access to ...
متن کاملChromatin structure and dynamics: state-of-the-art.
A meeting entitled "Chromatin Structure and Dynamics: State-of-the-Art" organized by Jordanka Zlatanova and Sanford Leuba was held at the NIH from May 8-10, 2002. It was a timely meeting and addressed our current understanding of chromatin structure, dynamics, and function.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Cell
سال: 2002
ISSN: 1097-2765
DOI: 10.1016/s1097-2765(02)00581-6